Input form
- SpotOn requires a correctly-formatted PDB file of the complex of interest. In addition to the PDB file you need to define the chains that will be used in the analysis. Chains that are present in the PDB file but are not defined in the textboxes below will not be taken into account.
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You can find example input files here: EXAMPLE
- Supported by
- This work is co-funded by the Horizon 2020 projects EOSC-hub (grant number 777536) and BioExcel (grant numbers 823830 and 675728).
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no [MEMBRANEPROT 659826]. - Reference for use of the server
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When using the SpotOn server please cite:
Melo et al (2016)
A Machine Learning Approach for Hot-Spot Detection at Protein-Protein Interfaces.
Int. J. Mol. Sci. 17, 1215.
Moreira and Koukos et al. (2017)
SpotOn: High Accuracy Identification of Protein-Protein Interface Hot-Spots.
Scientific Reports 7:8007.
